delta24(24-1) sterol reductase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.71 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a Delta24(241)-sterol reductase (EC 1.3.1.71) is an enzyme that catalyzes the chemical reaction
- ergosterol + NADP ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H
Thus, the two substrates of this enzyme are ergosterol and NADP, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.
References
- Neal WD, Parks LW (1977). "Sterol 24(28) methylene reductase in Saccharomyces cerevisiae". J. Bacteriol. 129 (3): 1375–8. PMC 235112. PMID 14922.
- Zweytick D, Hrastnik C, Kohlwein SD, Daum G (2000). "Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae". FEBS Lett. 470 (1): 83–7. doi:10.1016/S0014-5793(00)01290-4. PMID 10722850.
Oxidoreductases: CH–CH oxidoreductases (EC 1.3) | |
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1.3.1: NAD/NADP acceptor | |
1.3.3: Oxygen acceptor | |
1.3.5: Quinone | |
1.3.99: Other acceptors |
Enzymes | |
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Activity | |
Regulation | |
Classification | |
Kinetics | |
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