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DEFB106A
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2LWL
Identifiers
Aliases	DEFB106A, BD-6, DEFB-6, DEFB106, defensin beta 106A
External IDs	HomoloGene: 134659; GeneCards: DEFB106A; OMA:DEFB106A - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p23.1 Start 7,825,139 bp End 7,829,053 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver cell somatic cell white blood cell monocyte blood human musculoskeletal system right lobe of liver skeletal muscle muscle of leg n/a More reference expression data BioGPS n/a
Gene ontology Molecular function lipopolysaccharide binding heparin binding protein binding CCR2 chemokine receptor binding Cellular component extracellular region nucleus cell surface extrinsic component of membrane microvesicle membrane Biological process defense response defense response to bacterium innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245909 n/a Ensembl ENSG00000186579 ENSG00000285617 n/a UniProt Q8N104 n/a RefSeq (mRNA) NM_152251 n/a RefSeq (protein) NP_689464 n/a Location (UCSC) Chr 8: 7.83 – 7.83 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.

Function

The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.

References

1. ^ ENSG00000285617 GRCh38: Ensembl release 89: ENSG00000186579, ENSG00000285617 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
4. ^ "Entrez Gene: DEFB106A defensin, beta 106A".
5. Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi:10.3892/mmr.2013.1768. PMID 24189797.

Further reading

• Yamaguchi Y, Nagase T, Makita R, et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human -defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX 10.1.1.108.7808. doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
• Semple CA, Rolfe M, Dorin JR (2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
• Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683. PMID 12916016.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Taudien S, Galgoczy P, Huse K, et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence". BMC Genomics. 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC 544879. PMID 15588320.
• Boniotto M, Ventura M, Eskdale J, et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
• Patil AA, Cai Y, Sang Y, et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract". Physiol. Genomics. 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865. S2CID 22355626.

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