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DHRS9
Identifiers
Aliases	DHRS9, 3-alpha-HSD, 3ALPHA-HSD, RDH-E2, RDH-TBE, RDH15, RDHL, RDHTBE, RETSDR8, SDR9C4, dehydrogenase/reductase (SDR family) member 9, dehydrogenase/reductase 9
External IDs	OMIM: 612131; MGI: 2442798; HomoloGene: 26079; GeneCards: DHRS9; OMA:DHRS9 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q31.1 Start 169,064,789 bp End 169,096,167 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C2 Start 69,210,789 bp End 69,234,877 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nasal epithelium epithelium of nasopharynx epithelium of bronchus bronchial epithelial cell mucosa of transverse colon palpebral conjunctiva mucosa of sigmoid colon mucosa of ileum olfactory zone of nasal mucosa sperm Top expressed in granulocyte esophagus placenta lip yolk sac ileum jejunum zone of skin ovary stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity testosterone dehydrogenase (NAD+) activity alcohol dehydrogenase (NAD+) activity racemase and epimerase activity NAD-retinol dehydrogenase activity androsterone dehydrogenase activity androstan-3-alpha,17-beta-diol dehydrogenase activity Cellular component intracellular membrane-bounded organelle organelle membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process retinoic acid biosynthetic process retinol metabolic process 9-cis-retinoic acid biosynthetic process epithelial cell differentiation androgen metabolic process progesterone metabolic process lipid metabolism steroid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10170 241452 Ensembl ENSG00000073737 ENSMUSG00000027068 UniProt Q9BPW9 Q58NB6 RefSeq (mRNA) NM_001142270 NM_001142271 NM_001289763 NM_005771 NM_199204 NM_001376924 NM_175512 RefSeq (protein) NP_001135742 NP_001135743 NP_001276692 NP_954674 NP_001363853 NP_780721 Location (UCSC) Chr 2: 169.06 – 169.1 Mb Chr 2: 69.21 – 69.23 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dehydrogenase/reductase SDR family member 9 is an enzyme that in humans is encoded by the DHRS9 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000073737 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027068 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Soref CM, Di YP, Hayden L, Zhao YH, Satre MA, Wu R (Jun 2001). "Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol". J Biol Chem. 276 (26): 24194–202. doi:10.1074/jbc.M100332200. PMID 11304534.
6. Chetyrkin SV, Belyaeva OV, Gough WH, Kedishvili NY (Jun 2001). "Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties". J Biol Chem. 276 (25): 22278–86. doi:10.1074/jbc.M102076200. PMID 11294878.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
8. "Entrez Gene: DHRS9 dehydrogenase/reductase (SDR family) member 9".

Further reading

• Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN 978-0-12-182217-0. PMID 10800688.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Markova NG, Pinkas-Sarafova A, Karaman-Jurukovska N, et al. (2003). "Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase". Mol. Genet. Metab. 78 (2): 119–35. doi:10.1016/S1096-7192(02)00226-3. PMID 12618084.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Jette C, Peterson PW, Sandoval IT, et al. (2004). "The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L." J. Biol. Chem. 279 (33): 34397–405. doi:10.1074/jbc.M314021200. PMID 15190067.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jones RJ, Dickerson S, Bhende PM, et al. (2007). "Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9". J. Biol. Chem. 282 (11): 8317–24. doi:10.1074/jbc.M608667200. PMID 17244623.
• Riquelme P, Amodio G, Macedo C, Moreau A, Obermajer N, Brochhausen C, Ahrens N, Kekarainen T, Faendrich F, Cuturi C, Gregori S, Metes D, Schlitt HJ, Thomson AW, Geissler EK, Hutchinson JA (2017). "DHRS9 Is a Stable Marker of Human Regulatory Macrophages". Transplantation. 101 (11): 2731–38. doi:10.1097/TP.0000000000001814. PMC 6319563. PMID 28594751.

External links

• DHRS9 human gene location in the UCSC Genome Browser.
• DHRS9 human gene details in the UCSC Genome Browser.

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