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DHX15
Identifiers
Aliases	DHX15, DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p, DEAH-box helicase 15, hPrp43
External IDs	OMIM: 603403; MGI: 1099786; HomoloGene: 1040; GeneCards: DHX15; OMA:DHX15 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.2 Start 24,517,441 bp End 24,584,554 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 C1 Start 52,307,545 bp End 52,347,856 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue tibia germinal epithelium mucosa of sigmoid colon visceral pleura skin of hip parietal pleura embryo ventricular zone skin of thigh Top expressed in primitive streak Gonadal ridge mandibular prominence maxillary prominence abdominal wall hair follicle medial ganglionic eminence cumulus cell human fetus somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding double-stranded RNA binding protein binding ATP binding helicase activity hydrolase activity nucleic acid binding RNA binding 3'-5' RNA helicase activity Cellular component U12-type spliceosomal complex nucleolus U2-type post-mRNA release spliceosomal complex cytoplasm nucleus nucleoplasm nuclear speck Biological process mRNA processing response to alkaloid response to toxic substance RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1665 13204 Ensembl ENSG00000109606 ENSMUSG00000029169 UniProt O43143 O35286 RefSeq (mRNA) NM_001358 NM_001042620 NM_007839 RefSeq (protein) NP_001349 NP_001036085 NP_031865 Location (UCSC) Chr 4: 24.52 – 24.58 Mb Chr 5: 52.31 – 52.35 Mb PubMed search
Wikidata
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Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. It may have tumor suppressor activity.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000109606 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029169 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Imamura O, Sugawara M, Furuichi Y (Dec 1997). "Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family". Biochem Biophys Res Commun. 240 (2): 335–40. doi:10.1006/bbrc.1997.7585. PMID 9388478.
6. ^ "Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15".
7. Ito S, Koso H, Sakamoto K (Oct 2017). "RNA helicase DHX15 acts as a tumour suppressor in glioma". Br J Cancer. 117 (9): 1349–1359. doi:10.1038/bjc.2017.273. PMC 5672939. PMID 28829764.

Further reading

• Lüking A, Stahl U, Schmidt U (1998). "The protein family of RNA helicases". Crit. Rev. Biochem. Mol. Biol. 33 (4): 259–96. doi:10.1080/10409239891204233. PMID 9747670.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fouraux MA, Kolkman MJ, Van der Heijden A, et al. (2002). "The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase". RNA. 8 (11): 1428–43. doi:10.1017/S1355838202021076. PMC 1370349. PMID 12458796.
• Ono Y, Ohno M, Shimura Y (1994). "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22". Mol. Cell. Biol. 14 (11): 7611–20. doi:10.1128/MCB.14.11.7611. PMC 359297. PMID 7935475.

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