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DIDS

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DIDS
Skeletal formula
Ball-and-stick model
Names
Preferred IUPAC name 2,2′-(Ethene-1,2-diyl)bis(5-isothiocyanatobenzene-1-sulfonic acid)
Other names 5-Isothiocyanato-2-benzenesulfonic acid
Identifiers
CAS Number
3D model (JSmol)
Abbreviations DIDS
Beilstein Reference 6543839
ChEBI
ChemSpider
ECHA InfoCard 100.152.489 Edit this at Wikidata
IUPHAR/BPS
KEGG
MeSH 4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)Key: YSCNMFDFYJUPEF-UHFFFAOYSA-N
SMILES
  • OS(=O)(=O)C1=C(C=CC2=C(C=C(C=C2)N=C=S)S(O)(=O)=O)C=CC(=C1)N=C=S
Properties
Chemical formula C16H10N2O6S4
Molar mass 454.50 g·mol
Melting point 400 °C (752 °F; 673 K)
log P 4.72
Acidity (pKa) -3.21, -1.428, -0.37, 0.23
Basicity (pKb) 13.77, 14.37, 15.425, 17.21
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.

References

  1. Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology, 92 (3): 195–205, doi:10.1007/BF01869388, PMID 3783658, S2CID 19244281
  2. Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction, 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526
Glutamate metabolism and transport modulators
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators
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