Misplaced Pages

DIXDC1

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Protein-coding gene in humans
DIXDC1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3PZ7

Identifiers
AliasesDIXDC1, CCD1, DIX domain containing 1
External IDsOMIM: 610493; MGI: 2679721; HomoloGene: 82369; GeneCards: DIXDC1; OMA:DIXDC1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)
Chromosome 11 (human)Genomic location for DIXDC1Genomic location for DIXDC1
Band11q23.1Start111,927,144 bp
End112,022,653 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for DIXDC1Genomic location for DIXDC1
Band9|9 A5.3Start50,574,052 bp
End50,650,817 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • inferior ganglion of vagus nerve

  • corpus callosum

  • urethra

  • saphenous vein

  • superficial temporal artery

  • subthalamic nucleus

  • ventral tegmental area

  • synovial joint

  • mucosa of paranasal sinus
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • habenula

  • superior colliculus

  • pontine nuclei

  • epithelium of lens

  • dorsomedial hypothalamic nucleus

  • ventral tegmental area

  • neural layer of retina

  • medial dorsal nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85458

330938

Ensembl

ENSG00000150764

ENSMUSG00000032064

UniProt

Q155Q3

Q80Y83

RefSeq (mRNA)

NM_001037954
NM_001278542
NM_033425

NM_178118
NM_001311069
NM_001374656

RefSeq (protein)

NP_001033043
NP_001265471
NP_219493

NP_001297998
NP_835219
NP_001361585

Location (UCSC)Chr 11: 111.93 – 112.02 MbChr 9: 50.57 – 50.65 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Dixin is a protein that in humans is encoded by the DIXDC1 gene. When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000150764Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032064Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Katoh M, Katoh M (July 2003). "KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain". International Journal of Oncology. 23 (1): 145–50. doi:10.3892/ijo.23.1.145. PMID 12792787.
  6. "Entrez Gene: DIXDC1 DIX domain containing 1".
  7. "New gene discovered that stops the spread of deadly cancer".

Further reading

Stub icon

This article on a gene on human chromosome 11 is a stub. You can help Misplaced Pages by expanding it.

Categories: