DPB may stand for:
Government
- Domestic Purposes Benefit, in the New Zealand social security system
- Defense Policy Board, of the US Department of Defense
- Dental Practice Board, a UK government agency now incorporated into the NHS Business Services Authority
Science and technology
- Decoded Picture Buffer, used by video decoders
- Diffuse panbronchiolitis, a lung disease
- Disinfection by-product, in water treatment
Transport
- Deer Park Bypass, Melbourne, Australia
- USCG deployable pursuit boat
- Dopravný podnik Bratislava, a Slovakian public transport operator
Other uses
- Deutscher Pfadfinderbund (1945)
- Discounted Payback, an engineering economics measure
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