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DPYS

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Protein-coding gene in the species Homo sapiens
DPYS
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2VR2

Identifiers
AliasesDPYS, dihydropyrimidinase, DHP, DHPase
External IDsOMIM: 613326; MGI: 1928679; HomoloGene: 20359; GeneCards: DPYS; OMA:DPYS - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)
Chromosome 8 (human)Genomic location for DPYSGenomic location for DPYS
Band8q22.3Start104,330,324 bp
End104,467,055 bp
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)
Chromosome 15 (mouse)Genomic location for DPYSGenomic location for DPYS
Band15|15 B3.1Start39,631,883 bp
End39,720,866 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • kidney tubule

  • glomerulus

  • metanephric glomerulus

  • human kidney

  • right adrenal cortex

  • left adrenal cortex

  • testicle

  • gonad

  • mucosa of paranasal sinus
Top expressed in
  • left lobe of liver

  • primary oocyte

  • proximal tubule

  • right kidney

  • respiratory epithelium

  • olfactory epithelium

  • zygote

  • secondary oocyte

  • embryo

  • spermatid
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1807

64705

Ensembl

ENSG00000147647

ENSMUSG00000022304

UniProt

Q14117

Q9EQF5

RefSeq (mRNA)

NM_001385

NM_001164466
NM_022722

RefSeq (protein)

NP_001376

NP_001157938
NP_073559

Location (UCSC)Chr 8: 104.33 – 104.47 MbChr 15: 39.63 – 39.72 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

[[File:
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ] ]
FluoropyrimidineActivity_WP1601go to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to PubChem Compoundgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to pathway articlego to pathway articlego to articlego to articlego to articlego to articlego to articlego to WikiPathwaysgo to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Fluorouracil (5-FU) Activity edit]] Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000147647Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022304Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
  6. ^ "Entrez Gene: DPYS dihydropyrimidinase".

Further reading

Purine metabolism
Anabolism
R5PIMP:
IMP→AMP:
IMP→GMP:
Nucleotide salvage
Catabolism
Pyrimidine metabolism
Anabolism
Catabolism
Deoxyribonucleotides


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