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DTX3
Identifiers
Aliases	DTX3, RNF154, deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3
External IDs	OMIM: 613142; MGI: 2135752; HomoloGene: 12754; GeneCards: DTX3; OMA:DTX3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 57,604,622 bp End 57,609,804 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 127,190,378 bp End 127,195,728 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right frontal lobe right uterine tube endothelial cell left ovary body of uterus right ovary anterior cingulate cortex nucleus accumbens Top expressed in neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex ventricular zone habenula dorsomedial hypothalamic nucleus piriform cortex spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding transferase activity zinc ion binding Cellular component cytoplasm Biological process Notch signaling pathway protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196403 80904 Ensembl ENSG00000178498 ENSMUSG00000040415 UniProt Q8N9I9 Q80V91 RefSeq (mRNA) NM_001286245 NM_001286246 NM_178502 NM_030714 NM_001368332 RefSeq (protein) NP_001273174 NP_001273175 NP_848597 NP_109639 NP_001355261 Location (UCSC) Chr 12: 57.6 – 57.61 Mb Chr 10: 127.19 – 127.2 Mb PubMed search
Wikidata
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Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene. It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c. DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.

Function

DTX3 functions as an E3 ubiquitin ligase. Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000178498 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000040415 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26.
6. ^ Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.
7. Takeyama, Kunihiko; Aguiar, Ricardo C. T.; Gu, Liqun; He, Chunyan; Freeman, Gordon J.; Kutok, Jeffery L.; Aster, Jon C.; Shipp, Margaret A. (2003-06-13). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937. doi:10.1074/jbc.M301157200. ISSN 0021-9258. PMID 12670957.

Further reading

• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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