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DTX4
Identifiers
Aliases	DTX4, RNF155, deltex 4, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 4
External IDs	OMIM: 616110; MGI: 2672905; HomoloGene: 27781; GeneCards: DTX4; OMA:DTX4 - orthologs
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 12,443,702 bp End 12,478,818 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus olfactory bulb inferior ganglion of vagus nerve subthalamic nucleus spinal cord superior vestibular nucleus ventral tegmental area Pons trigeminal ganglion bronchus Top expressed in otolith organ utricle transitional epithelium of urinary bladder white adipose tissue efferent ductule Gonadal ridge migratory enteric neural crest cell superior cervical ganglion central gray substance of midbrain skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytosol cytoplasm Biological process protein ubiquitination regulation of type I interferon production Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23220 207521 Ensembl n/a ENSMUSG00000039982 UniProt Q9Y2E6 Q6PDK8 RefSeq (mRNA) NM_001300727 NM_015177 NM_172442 NM_001401392 RefSeq (protein) NP_001287656 NP_055992 NP_766030 NP_001388321 Location (UCSC) n/a Chr 19: 12.44 – 12.48 Mb PubMed search
Wikidata
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Deltex E3 ubiquitin ligase 4 is a protein that in humans is encoded by the DTX4 gene.

References

1. ^ GRCm38: Ensembl release 89: ENSMUSG00000039982 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Deltex E3 ubiquitin ligase 4". Retrieved 2018-07-05.

Further reading

• Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang HY, Wang RF (March 2012). "NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4". Nat. Immunol. 13 (4): 387–95. doi:10.1038/ni.2239. PMC 3760161. PMID 22388039.

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