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DYNLT3
Identifiers
Aliases	DYNLT3, RP3, TCTE1L, TCTEX1L, dynein light chain Tctex-type 3
External IDs	OMIM: 300302; MGI: 1914367; HomoloGene: 21304; GeneCards: DYNLT3; OMA:DYNLT3 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.4 Start 37,836,757 bp End 37,847,571 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A1.1 Start 9,520,506 bp End 9,529,242 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium Pons dorsal motor nucleus of vagus nerve pars compacta Brodmann area 23 lateral nuclear group of thalamus optic nerve oral cavity glomerulus Top expressed in Epithelium of choroid plexus transitional epithelium of urinary bladder seminal vesicula deep cerebellar nuclei medial vestibular nucleus retinal pigment epithelium lateral geniculate nucleus epithelium of lens conjunctival fornix facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity protein binding identical protein binding Cellular component cytoplasm kinetochore chromosome dynein complex cytoplasmic dynein complex microtubule chromosome, centromeric region cytoskeleton nucleus mitotic spindle astral microtubule Biological process cell cycle regulation of mitotic cell cycle cell division positive regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6990 67117 Ensembl ENSG00000165169 ENSMUSG00000031176 UniProt P51808 P56387 RefSeq (mRNA) NM_006520 NM_025975 RefSeq (protein) NP_006511 NP_080251 Location (UCSC) Chr X: 37.84 – 37.85 Mb Chr X: 9.52 – 9.53 Mb PubMed search
Wikidata
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Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.

Function

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase. DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.

Interactions

DYNLT3 has been shown to interact with VDAC1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000165169 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000031176 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: DYNLT3 dynein, light chain, Tctex-type 3".
6. Roux AF, Rommens J, McDowell C, Anson-Cartwright L, Bell S, Schappert K, Fishman GA, Musarella M (February 1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.
7. Lo KW, Kogoy JM, Pfister KK (April 2007). "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3". J. Biol. Chem. 282 (15): 11205–12. doi:10.1074/jbc.M611279200. PMID 17289665.
8. Yeh TY, Chuang JZ, Sung CH (August 2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
9. Schwarzer, Christian; Barnikol-Watanabe Shitsu; Thinnes Friedrich P; Hilschmann Norbert (Sep 2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. ISSN 1357-2725. PMID 12009301. S2CID 11632830.

Further reading

• Roux AF, Rommens J, McDowell C, et al. (1994). "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex". Hum. Mol. Genet. 3 (2): 257–63. doi:10.1093/hmg/3.2.257. PMID 8004092.
• Bauch A, Campbell KS, Reth M (1998). "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta". Eur. J. Immunol. 28 (7): 2167–77. doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L. PMID 9692886. S2CID 21656634.
• Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. doi:10.1016/S1357-2725(02)00026-2. PMID 12009301. S2CID 11632830.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• O'Rourke SM, Dorfman MD, Carter JC, Bowerman B (2007). "Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants". PLOS Genet. 3 (8): e128. doi:10.1371/journal.pgen.0030128. PMC 1937013. PMID 17676955.

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