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Daf-5

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Protein-coding gene in the species Caenorhabditis elegans
Dauer Formation abnormality gene 5
Identifiers
OrganismCaenorhabditis elegans
SymbolDaf-5
Entrez175054
RefSeq (mRNA)NM_064540.5
RefSeq (Prot)NP_496941.1
UniProtG5EDM7
Other data
ChromosomeII: 14.03 - 14.04 Mb
Search for
StructuresSwiss-model
DomainsInterPro

Daf-5 is an ortholog of the mammalian protein Sno/Ski，which present in the nematode worm Caenorhabditis elegans on the downstream of TGFβ signaling pathway. Without daf-7 signal, daf-5 combined with daf-3, co-SMAD for C. elegans, to form a heterodimer and started dauer development.

References

  1. da Graca LS, Zimmerman KK, Mitchell MC, Kozhan-Gorodetska M, Sekiewicz K, Morales Y, Patterson GI (January 2004). "DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development". Development. 131 (2): 435–46. doi:10.1242/dev.00922. PMID 14681186. S2CID 31708102.
  2. Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.
Dauer larva related genes
Dauer Formation Abnormal protein
Downstream Of Daf protein
Daf-12-interacting protein
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