DeLuise or De Luise may refer to:
- Members of the DeLuise family of entertainers:
- Dom DeLuise (1933–2009), American actor and comedian
- Carol DeLuise (1935–2020), American actress known professionally as Carol Arthur; wife of Dom
- Peter DeLuise (born 1966), American actor, television director, and television producer; son of Dom and Carol
- Anne Marie DeLuise (born 1969), Canadian actress; wife of Peter
- Michael DeLuise (born 1969), American former actor; son of Dom and Carol
- David DeLuise (born 1971), American actor; son of Dom and Carol
- Fiore De Luise (born 1977), Italian astronomer
- 84012 Deluise, a minor planet discovered in 2002 and named for De Luise
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