De Los Santos, also spelled delos Santos in the Philippines, is a Spanish surname meaning "of the saints". Notable people with the surname include:
- Abel De Los Santos (born 1992), American baseball player
- Alejandro de los Santos (1902–1982), Argentinian football player
- Enyel De Los Santos (born 1995), Dominican Republic baseball player
- Epifanio de los Santos (1871–1928), Filipino historian
- Fautino de los Santos (born 1986), Dominican Republic baseball player
- Gonzalo de los Santos (born 1976), Uruguayan football player
- Jaime de los Santos (born 1946), Filipino general
- Ramón de los Santos (1949—2015), Dominican Republic baseball player
- Valerio de los Santos (born 1972), Dominican Republic baseball player
- William de los Santos, (born 1964), actor
- Homer Delos Santos (born 1993), Project Evaluation Assistant in DENR - Environmental Management Bureau Solid Waste Management Division
- Yerry De Los Santos (born 1997), Dominican Republic baseball player
- Arvin De Los Santos (born 2000), artist from the Philippines
See also
- 33219 De Los Santos, an asteroid
- Epifanio de los Santos Avenue
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