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Decaprenylphospho-beta-D-ribofuranose 2-oxidase

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Decaprenylphospho-beta-D-ribofuranose 2-oxidase
Identifiers
EC no.1.1.98.3
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Decaprenylphospho-beta-D-ribofuranose 2-oxidase (EC 1.1.98.3, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, Rv3790, DprE1) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase. This enzyme catalyses the following chemical reaction

trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD {\displaystyle \rightleftharpoons } trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2

This enzyme from the bacterium Mycobacterium smegmatis participates in epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose.

References

  1. Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, Chiarelli LR, Mori G, Kim J, Contreras-Dominguez M, Park YS, Han SJ, Brodin P, Valentini G, Rizzi M, Riccardi G, Pasca MR (2011). "Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis". PLOS ONE. 6 (11): e26675. Bibcode:2011PLoSO...626675D. doi:10.1371/journal.pone.0026675. PMC 3206020. PMID 22069462.
  2. Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K (January 2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1". Journal of the American Chemical Society. 134 (2): 912–5. doi:10.1021/ja211042r. PMID 22188377.

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Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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