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Dehydrocorybulbine

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Dehydrocorybulbine
Names
IUPAC name 3-Hydroxy-2,9,10-trimethoxy-13-methyl-7,8,13,13a-tetradehydroberbin-7-ium
Systematic IUPAC name 3-Hydroxy-2,9,10-trimethoxy-13-methyl-5,6-dihydro-7λ-isoquinolinoisoquinolin-7-ylium
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C21H21NO4/c1-12-14-5-6-18(24-2)21(26-4)16(14)11-22-8-7-13-9-17(23)19(25-3)10-15(13)20(12)22/h5-6,9-11H,7-8H2,1-4H3/p+1Key: XWCVASCMRTXXRY-UHFFFAOYSA-O
SMILES
  • O(c4cc3c2c(c1ccc(OC)c(OC)c1c2CCc3cc4O)C)C
Properties
Chemical formula C21H22NO4
Molar mass 352.40 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Dehydrocorybulbine (DHCB) is an alkaloid isolated from Corydalis yanhusuo. Dehydrocorybulbine binds to the dopamine D1 receptor.

Research has indicated that DHCB can be helpful in reducing neuropathic pain.

References

  1. "KNApSAcK Metabolite Information - 59870-72-3". www.knapsackfamily.com.
  2. ^ Ma, ZZ; Xu, W; Jensen, NH; Roth, BL; Liu-Chen, LY; Lee, DY (2008). "Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor". Molecules (Basel, Switzerland). 13 (9): 2303–12. doi:10.3390/molecules13092303. PMC 6245449. PMID 18830156.
  3. Chinese herbal compound relieves inflammatory and neuropathic pain
  4. A Novel Analgesic Isolated from a Traditional Chinese Medicine. Current Biology. Volume 24, Issue 2, p117–123, 20 January 2014


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