Department of the Interior usually refers to the United States Department of the Interior.
Department of the Interior may also refer to:
- Department of the Interior (1932–39), an Australian government department that existed 1932–1939
- Department of the Interior (1939–72), an Australian government department that existed 1939–1972
- Ministry of Interior, a government department typically responsible for policing, emergency management, national security, elections, and immigration
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