Derderian or Derderyan (Armenian: Դերդերյան) is an Armenian surname. "Derder" (Դերդերյ) in Armenian means priest. Notable people with the surname include:
- Hovnan Derderian (born 1957), Lebanese-Armenian Apostolic archbishop
- Mariana Derderian (born 1980), Chilean actress
- Yeghishe Derderian of Jerusalem (1911–1990), Armenian bishop and scholar
- Viguen Derderian (1929–2003), Iranian singer
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