Desmond Lee may refer to:
- Desmond Lee (classical scholar) (1908–1993), English classical scholar
- Desmond Lee (Singaporean politician) (born 1976)
- Desmond Lee (Hong Kong politician) (born 1944)
- Desmond Lee (basketball) (born 1990)
- Des Lee, musician in The Miami Showband
See also
- Desmond Lee-Wortley, character in The Adventure of the Christmas Pudding
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