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Dichloroarcyriaflavin A synthase (EC 1.13.12.17) is an enzyme with systematic name dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming). This enzyme catalyses the following chemical reaction:

dichlorochromopyrrolate + 4 O₂ + 4 NADH + 4 H ${\displaystyle \rightleftharpoons }$ dichloroarcyriaflavin A + 2 CO₂ + 6 H₂O + 4 NAD

RebP is an NAD-dependent cytochrome P450 oxygenase that performs an aryl-aryl bond formation.

References

1. Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S (July 2007). "Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11591–6. Bibcode:2007PNAS..10411591M. doi:10.1073/pnas.0702946104. PMC 1913897. PMID 17606921.
2. Howard-Jones AR, Walsh CT (September 2006). "Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid". Journal of the American Chemical Society. 128 (37): 12289–98. doi:10.1021/ja063898m. PMID 16967980.
3. Sánchez C, Zhu L, Braña AF, Salas AP, Rohr J, Méndez C, Salas JA (January 2005). "Combinatorial biosynthesis of antitumor indolocarbazole compounds". Proceedings of the National Academy of Sciences of the United States of America. 102 (2): 461–6. doi:10.1073/pnas.0407809102. PMC 544307. PMID 15625109.

External links

• Dichloroarcyriaflavin+A+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

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