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Disseminated disease can refer to disseminated cancer which is the movement of cancerous cells from the original tumor to other areas of the body, or disseminated infection which is the pathogen's entry into the host, growth, and dissemination, which results in illness.

After exiting the main tumor, cancer cells circulate throughout the body. They are known as circulating tumor cells once they are in the blood. Few circulating tumor cells can disseminate to distant locations and remain tumor cells. The amount of disseminated tumor cells that can develop into metastases is even lower.

See also

• Metastasis
• Localized disease

References

1. Albert, WH; Hauch, S; Zieglschmid, V (2005). "Detection of Disseminated Cancer Cells in Blood". EJIFCC. 16 (2). International Federation of Clinical Chemistry and Laboratory Medicine: 81–85. PMC 6008966. PMID 29942243.
2. Ellis, Simon; Ong, Edmund (2015). "Disseminated Infections". Molecular Medical Microbiology. Elsevier. pp. 637–653. doi:10.1016/b978-0-12-397169-2.00036-6. ISBN 978-0-12-397169-2.
3. Dasgupta, Arko; Lim, Andrea R.; Ghajar, Cyrus M. (2017). "Circulating and disseminated tumor cells: harbingers or initiators of metastasis?". Molecular Oncology. 11 (1). Wiley: 40–61. doi:10.1002/1878-0261.12022. ISSN 1574-7891. PMC 5423226. PMID 28085223.

Further reading

• Albert, WH; Hauch, S; Zieglschmid, V (2005). "Detection of Disseminated Cancer Cells in Blood". EJIFCC. 16 (2). International Federation of Clinical Chemistry and Laboratory Medicine: 81–85. PMC 6008966. PMID 29942243.
• Ramamoorthi, Ganesan; Kodumudi, Krithika; Gallen, Corey; Zachariah, Nadia Nocera; Basu, Amrita; Albert, Gabriella; Beyer, Amber; Snyder, Colin; Wiener, Doris; Costa, Ricardo L.B.; Czerniecki, Brian J. (2022). "Disseminated cancer cells in breast cancer: Mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities". Seminars in Cancer Biology. 78. Elsevier BV: 78–89. doi:10.1016/j.semcancer.2021.02.004. ISSN 1044-579X. PMID 33626407.

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