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Djaja D. Soejarto is an Indonesian-born botanist, ethnobotanist, pharmacognosist, academic and author. He is an adjunct curator at the Field Museum of Natural History as well as professor emeritus in the Department of Pharmaceutical Sciences and at the Pharmacognosy Institute of the College of Pharmacy, the University of Illinois at Chicago.

Soejarto is most known for his works on medicinal plants of Southeast Asia. His works have been published in academic journals, including Economic Botany and Journal of Natural Products, as well as books such as Ethnobotany of Tuberculosis in Laos and Medicinal Plants of Laos. He is the recipient of the 2022 Tyler Prize Award from the American Society of Pharmacognosy.

Soejarto was the editor of the Journal of Ethnopharmacology.

Education

Soejarto completed his BSc from the College of Agriculture in Java in 1962, followed by an M.A. in biology from Harvard University. In 1969, he obtained a PhD in biology from the same institution.

Career

Soejarto joined the University of Antioquia in 1971, where he undertook various roles, serving as an assistant professor in the Department of Biology from 1971 to 1973 and subsequently as an associate professor in the same department from 1973 to 1976. Between 1979 and 1983, he served as an adjunct associate professor of pharmacognosy in the Department of Pharmacognosy and Pharmacology, College of Pharmacy at the University of Illinois at Chicago. At the University of Illinois Chicago, he held multiple positions, including an appointment as an associate professor in the Department of Medicinal Chemistry and Pharmacognosy and Program for Collaborative Research in the Pharmaceutical Sciences from 1983 to 1989. From 1989 to 2014, he held the position of professor of pharmacognosy. Concurrently, he held the position of an affiliate professor of biology at the same institution from 1990 to 1995. Since 2015, he has held the position of professor emeritus in the Department of Pharmaceutical Sciences and Program for Collaborative Research in the Pharmaceutical Sciences at the University of Illinois at Chicago.

Soejarto founded the Herbarium of the University of Antioquia in Medellin, Colombia, serving as its director from 1969 to 1976. Between 1991 and 1997, he held an honorary appointment as a researcher in the National Museum, Manila. Apart from this, he served in consulting roles at the Chinese Traditional Medicine Division of the Hong Kong Department of Health from 2009 to 2017. Since 2013, he has served as an adjunct curator in Science and Education at the Field Museum of Natural History. Furthermore, in collaboration with his chemistry colleagues, he has conducted fieldwork that led to the discovery of new drug lead compounds from plants he collected, primarily in Vietnam and Laos.

Works

Soejarto has authored books throughout his research career. In his book titled Ethnobotany of Tuberculosis in Laos, he explored traditional healing practices in Laos, presenting previously unpublished photographs of medicinal plants from the region. The book also provided a comprehensive account of newly isolated medically interesting compounds from the genus Marsypopetalum (Annonaceae), marking the first documentation of such compounds from this genus.

Research

Focusing on endangered or threatened plant species growing in the United States, Soejarto's 1985 study projected the extinction of 2,067 valuable medicinal plants by 2000, estimating their collective value at $3.248 billion. The research also underscored the necessity of safeguarding these plants to secure the future availability of essential prescription drugs. In the same year, he explored the use of locally available plants or plant extracts for primary health care by presenting a list of plant-derived drugs their sources, and therapeutic uses, aiming to identify alternatives to pharmaceutical preparations. His 1995 collaborative study with JT Baker and others discussed the shift in attitudes towards global genetic resources, emphasizing the importance of conserving these resources and indigenous knowledge through international collaboration, fair compensation, and the implementation of policies outlined in the United Nations Convention on Biological Diversity. Furthermore, in papers published in 2004 and 2007, he provided a factual model on the equitable sharing of benefits in a north–south bioprospecting endeavor between the University of Illinois at Chicago and the Vietnam Academy of Science and Technology, Hanoi, Vietnam, on the one hand, and the Institute of Traditional Medicine, Ministry of Health, Lao People's Democratic Republic, on the other.

Soejarto has also worked in the identification of tropical plant materials for research in developing anticancer and anti-HIV drugs. His research has contributed to the discovery and subsequent advancement of bioactive molecules. Notably, he identified the source plant of the anti-HIV active lead compounds calanolides A and B from Calophyllum lanigerum and C. teysmannii (Clusiaceae) in Sarawak, Malaysia, as well as anticancer active lead compounds phyllanthusmins C and D from Phyllanthus poilanei (Euphorbiaceae) collected in Vietnam. Additionally, he also investigated the potential sweetening agents of plant origin. In one of his studies, he explored the organoleptic qualities of 184 Stevia leaf samples, highlighting that a 62-year-old leaf of S. rebaudiana retained significant and lasting sweetness through diverse preservation methods. It further identified 18 other species and varieties for potential phytochemical investigation of ent-kaurene glycosides. His 2005 collaborative research with A Koch and others delved into Maasai herbalists' traditional knowledge of malaria treatment, revealing 21 plant species through interviews, with in vitro assays confirming the antiplasmodial efficacy of more than half, highlighting ethnomedical inquiry's potential for antimalarial drug discovery. Furthermore, he previously led the Vietnam-Laos International Cooperative Biodiversity Group (ICBG) project from 1998 to 2012. This research explored and identify novel bioactive compounds from plants in Vietnam and Laos for potential therapeutic applications against HIV/AIDS, cancer, tuberculosis, and malaria.

Bibliography

Books

• Ethnobotany of Tuberculosis in Laos (2014) ISBN 9783319106557
• Medicinal Plants of Laos (2023) ISBN 9781032077772

Selected articles

• Soejarto, D. D., Kinghorn, A. D., & Farnsworth, N. R. (1982). Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. Journal of natural products, 45(5), 590–599.
• Farnsworth, N. R., Akerele, O., Bingel, A. S., Soejarto, D. D., & Guo, Z. (1985). Medicinal plants in therapy. Bulletin of the world health organization, 63(6), 965.
• Farnsworth, N. R., & Soejarto, D. D. (1985). Potential consequence of plant extinction in the United States on the current and future availability of prescription drugs. Economic botany, 39(3), 231–240.
• Baker, J. T., Borris, R. P., Carté, B., Cordell, G. A., Soejarto, D. D., Cragg, G. M., ... & Tyler, V. E. (1995). Natural product drug discovery and development: new perspectives on international collaboration. Journal of natural products, 58(9), 1325–1357.
• Koch, A., Tamez, P., Pezzuto, J., & Soejarto, D. (2005). Evaluation of plants used for antimalarial treatment by the Maasai of Kenya. Journal of ethnopharmacology, 101(1–3), 95–99.

Selected book chapters

• Soejarto, D. D. (2001). Ethnobotany of Stevia and Stevia rebaudiana. In Stevia (pp. 40–67). CRC Press.
• Farnsworth, N. R., & Soejarto, D. D. (1991). Global importance of medicinal plants. The conservation of medicinal plants, 26(26), 25–51.
• Soejarto, D. D., Gyllenhaal, C., Tarzian Sorensen, J. A., Fong, H. H. H. S., Xuan, L. T., Binh, L. T., ... & Riley, M. C. (2007). Bioprospecting arrangements: Cooperation between the north and the south. Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices. MIHR.

References

1. ^ "Dr. Djaja Djendoel Soejarto | Discovery of Anticancer Agents of Diverse Natural Origin". u.osu.edu.
2. "Djaja D. Soejarto". scholar.google.com.
3. ^ "Ethnobotany of tuberculosis in Laos".
4. "Medicinal plants of Laos".
5. "Soejarto Named 2022 ASP Varro E. Tyler Award Winner" (PDF).
6. "Editorial board – Journal of Ethnopharmacology | ScienceDirect.com by Elsevier". www.sciencedirect.com.
7. "Herbario".
8. "Herbarium Details – Universidad de Antioquia".
9. • Regalado, Jacinto C.; Soejarto, Djaja D. (1997). "The Genus Microrphium (Gentianaceae) in the Philippines". Novon. 7 (1): 77–80. doi:10.2307/3392078. JSTOR 3392078 – via JSTOR.
   • Pérez, Lynette Bueno; Still, Patrick C.; Naman, C. Benjamin; Ren, Yulin; Pan, Li; Chai, Hee-Byung; Carcache de Blanco, Esperanza J.; Ninh, Tran Ngoc; Van Thanh, Bui; Swanson, Steven M.; Soejarto, Djaja D.; Kinghorn, A. Douglas (December 19, 2014). "Investigation of Vietnamese plants for potential anticancer agents". Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe. 13 (4): 727–739. Bibcode:2014PChRv..13..727B. doi:10.1007/s11101-014-9335-7. PMC 4225705. PMID 25395897.
   • Henkin, Joshua M.; Ren, Yulin; Soejarto, Djaja Djendoel; Kinghorn, A. Douglas (January 19, 2018). "The Search for Anticancer Agents from Tropical Plants". Progress in the Chemistry of Organic Natural Products vol. 107. Progress in the Chemistry of Organic Natural Products. pp. 1–94. doi:10.1007/978-3-319-93506-5_1. ISBN 978-3-319-93505-8. PMID 30178270 – via PubMed.
   • Carcache De Blanco, Esperanza J.; Addo, Ermias Mekuria; Rakotondraibe, H. Liva; Soejarto, Djaja D.; Kinghorn, A. Douglas (January 1, 2023). "Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study". Natural Product Reports. 40 (7): 1181–1197. doi:10.1039/d2np00080f. PMC 10524867. PMID 37194649. S2CID 258742136.
   • Zhang, Hong-Jie; Li, Wan-Fei; Fong, Harry H. S.; Soejarto, Djaja Doel (October 31, 2016). "Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998". Molecules. 21 (11): 1448. doi:10.3390/molecules21111448. PMC 6273581. PMID 27809237.
10. "Selected common plants at Cuc Phuong National Park".
11. Farnsworth, Norman R.; Soejarto, Djaja Doel (July 1, 1985). "Potential consequence of plant extinction in the United States on the current and future availability of prescription drugs". Economic Botany. 39 (3): 231–240. Bibcode:1985EcBot..39..231F. doi:10.1007/BF02858792. S2CID 43096557 – via Springer Link.
12. Farnsworth, Norman R.; Akerele, Olayiwola; Bingel, Audrey S.; Soejarto, Djaja D.; Guo, Zhengang (January 19, 1985). "Medicinal plants in therapy". Bulletin of the World Health Organization. 63 (6): 965–981. PMC 2536466. PMID 3879679.
13. Baker, J. T.; Borris, R. P.; Carté, B.; Cordell, G. A.; Soejarto, D. D.; Cragg, G. M.; Gupta, M. P.; Iwu, M. M.; Madulid, D. R.; Tyler, V. E. (September 19, 1995). "Natural product drug discovery and development: new perspectives on international collaboration". Journal of Natural Products. 58 (9): 1325–1357. doi:10.1021/np50123a003. PMID 7494142 – via PubMed.
14. Soejarto, D. D.; Gyllenhaal, C.; Fong, H. H. S.; Xuan, L. T.; Hiep, N. T.; Hung, N. V.; Bich, T. Q.; Southavong, B.; Sydara, K.; Pezzuto, J. M. (February 19, 2004). "The UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: a model of benefit-sharing arrangement in natural products drug discovery and development". Journal of Natural Products. 67 (2): 294–299. doi:10.1021/np0304363. PMID 14987071 – via PubMed.
15. Ren, Yulin; Lantvit, Daniel D.; Deng, Youcai; Kanagasabai, Ragu; Gallucci, Judith C.; Ninh, Tran Ngoc; Chai, Hee-Byung; Soejarto, Djaja D.; Fuchs, James R.; Yalowich, Jack C.; Yu, Jianhua; Swanson, Steven M.; Kinghorn, A. Douglas (June 27, 2014). "Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei". Journal of Natural Products. 77 (6): 1494–1504. doi:10.1021/np5002785. PMC 4073661. PMID 24937209.
16. Kinghorn, A. D.; Nanayakkara, N. P. D.; Soejarto, D. D.; Medon, P. J.; Kamath, S. (March 26, 1982). "Potential sweetening agents of plant origin: I. Purification of Stevia rebaudiana sweet constituents by droplet counter-current chromatography". Journal of Chromatography A. 237 (3): 478–483. doi:10.1016/S0021-9673(00)97636-2.
17. Soejarto, D. D.; Compadre, C. M.; Medon, P. J.; Kamath, S. K.; Kinghorn, A. D. (January 1, 1983). "Potential sweetening agents of plant origin. II. field search for sweet-tastingStevia species". Economic Botany. 37 (1): 71–79. Bibcode:1983EcBot..37...71S. doi:10.1007/BF02859308. S2CID 29272901 – via Springer Link.
18. Soejarto, D. D.; Kinghorn, A. D.; Farnsworth, N. R. (January 19, 1982). "Potential sweetening agents of plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness". Journal of Natural Products. 45 (5): 590–599. doi:10.1021/np50023a013. PMID 7153776 – via PubMed.
19. Koch, A.; Tamez, P.; Pezzuto, J.; Soejarto, D. (October 3, 2005). "Evaluation of plants used for antimalarial treatment by the Maasai of Kenya". Journal of Ethnopharmacology. 101 (1–3): 95–99. doi:10.1016/j.jep.2005.03.011. PMID 15878245 – via PubMed.
20. Libman, A.; Bouamanivong, S.; Southavong, B.; Sydara, K.; Soejarto, D. D. (July 19, 2006). "Medicinal plants: an important asset to health care in a region of Central Laos". Journal of Ethnopharmacology. 106 (3): 303–311. doi:10.1016/j.jep.2005.11.034. PMID 16473485 – via PubMed.
21. Elkington, B. G.; Southavong, B.; Sydara, K.; Souliya, O.; Vanthanouvong, M.; Nettavong, K.; Thammachack, B.; Pak, D. H.; Riley, M. C.; Franzblau, S. G.; Soejarto, D. D. (2009). "Full article: Biological evaluation of plants of Laos used in the treatment of tuberculosis in Lao traditional medicine". Pharmaceutical Biology. 47 (1): 26–33. doi:10.1080/13880200802398002. PMC 3071617. PMID 21479105.
22. "Studies on biodiversity of Vietnam and Laos: The UIC-based ICBG program".
23. International Plant Names Index.  Soejarto.

• American academics
• American botanical writers
• Harvard University alumni
• University of Illinois Chicago faculty
• 21st-century botanists
• 21st-century American botanists
• Living people
• 1939 births
• Indonesian emigrants to the United States
• Ethnobotanists