Misplaced Pages

In enzymology, a dolichyldiphosphatase (EC 3.6.1.43) is an enzyme that catalyzes the chemical reaction

dolichyl diphosphate + H₂O ${\displaystyle \rightleftharpoons }$ dolichyl phosphate + phosphate

Thus, the two substrates of this enzyme are dolichyl diphosphate and H₂O, whereas its two products are dolichyl phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dolichyl-diphosphate phosphohydrolase. Other names in common use include dolichol diphosphatase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl diphosphate phosphohydrolase, and Dol-P-P phosphohydrolase. This enzyme participates in n-glycan biosynthesis.

References

• Naumov AV, Shabalin YA, Vagabov VM, Kulaev IS. "Two pathways of dephosphorylation of dolichyl diphosphate in yeasts". Biochemistry. 50. Moscow: 551–556.

• Biology

• v
• t
• e

• EC 3.6.1
• Enzymes of unknown structure
• EC 3.6 stubs