Drinker is a surname. Notable people with the surname include:
- Elizabeth Sandwith Drinker (ca. 1735–1807), American Quaker diarist
- Edith May (pseudonym of Anne Drinker; 1827–1903), American poet
- Edward Drinker Cope (1840–1897), American paleontologist and comparative anatomist
- Henry Sturgis Drinker (1850–1937), American mechanical engineer, lawyer and author, president of Lehigh University
- Catherine Ann Drinker (1841–1922), American artist and author
- Henry Sandwith Drinker (1880–1965), American lawyer and musicologist
- Sophie Drinker (1888–1967), American amateur musician and musicologist
- Philip Drinker (1894–1972), American industrial hygienist who invented the first iron lung
- Cecil Kent Drinker (1887–1956), American physician and founder of the Harvard School of Public Health
- Katherine Rotan Drinker (1889–1956), American physician
- Catherine Drinker Bowen, born Catherine Drinker (1897–1973), American biographer
- Ernesta Drinker Ballard, born Ernesta Drinker (1920–2005), American feminist and horticulturist
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