Misplaced Pages

Respiratory droplet

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from Droplet infection) Type of particle formed by breathing For transmission by smaller aerosol particles, see Airborne transmission.
man sneezing, with droplets dispersing widely into the surrounding air
Some infectious diseases can be spread via respiratory droplets expelled from the mouth and nose, as when a person sneezes.

A respiratory droplet is a small aqueous droplet produced by exhalation, consisting of saliva or mucus and other matter derived from respiratory tract surfaces. Respiratory droplets are produced naturally as a result of breathing, speaking, sneezing, coughing, or vomiting, so they are always present in our breath, but speaking and coughing increase their number.

Droplet sizes range from < 1 μm to 1000 μm, and in typical breath there are around 100 droplets per litre of breath. So for a breathing rate of 10 litres per minute this means roughly 1000 droplets per minute, the vast majority of which are a few micrometres across or smaller. As these droplets are suspended in air, they are all by definition aerosols. However, large droplets (larger than about 100 μm, but depending on conditions) rapidly fall to the ground or another surface and so are only briefly suspended, while droplets much smaller than 100 μm (which is most of them) fall only slowly and so form aerosols with lifetimes of minutes or more, or at intermediate size, may initially travel like aerosols but at a distance fall to the ground like droplets ("jet riders").

These droplets can contain infectious bacterial cells or virus particles they are important factors in the transmission of respiratory diseases. In some cases, in the study of disease transmission a distinction between what are called "respiratory droplets" and what are called "aerosols" is made, with only larger droplets referred to as "respiratory droplets" and smaller ones referred to as "aerosols" but this arbitrary distinction has never been supported experimentally or theoretically, and is not consistent with the standard definition of an aerosol.

Description

Respiratory droplets from humans include various cells types (e.g. epithelial cells and cells of the immune system), physiological electrolytes contained in mucus and saliva (e.g. Na, K, Cl), and, potentially, various pathogens.

Droplets that dry in the air become droplet nuclei which float as aerosols and can remain suspended in air for considerable periods of time.

the distribution size of droplets in breath: it is very broad ranging from less than a micrometre, to a millimetre
The probability density function for droplets in the breath of someone speaking, as a function of diameter. Note that both axes are log scales, we breathe out droplets ranging in size from less than a micrometre to around a millimetre, and that we breathe out many more droplets around a micrometre across than larger droplets. Only the largest droplets, around a millimetre in size are visible, we cannot see the smaller ones.

The traditional hard size cutoff of 5 μm between airborne and respiratory droplets has been criticized as a false dichotomy not grounded in science, as exhaled particles form a continuum of sizes whose fates depend on environmental conditions in addition to their initial sizes. However, it has informed hospital based transmission based precautions for decades.

Formation

Respiratory droplets can be produced in many ways. They can be produced naturally as a result of breathing, talking, sneezing, coughing, or singing. They can also be artificially generated in a healthcare setting through aerosol-generating procedures such as intubation, cardiopulmonary resuscitation (CPR), bronchoscopy, surgery, and autopsy. Similar droplets may be formed through vomiting, flushing toilets, wet-cleaning surfaces, showering or using tap water, or spraying graywater for agricultural purposes.

Depending on the method of formation, respiratory droplets may also contain salts, cells, and virus particles. In the case of naturally produced droplets, they can originate from different locations in the respiratory tract, which may affect their content. There may also be differences between healthy and diseased individuals in their mucus content, quantity, and viscosity that affects droplet formation.

Transport

Human cough: effect of wind speed on the transport of respiratory droplets.
Main article: Wells curve

Different methods of formation create droplets of different size and initial speed, which affect their transport and fate in the air. As described by the Wells curve, the largest droplets fall sufficiently fast that they usually settle to the ground or another surface before drying out, and droplets smaller than 100 μm will rapidly dry out, before settling on a surface. Once dry, they become solid droplet nuclei consisting of the non-volatile matter initially in the droplet. Respiratory droplets can also interact with other particles of non-biological origin in the air, which are more numerous than them. When people are in close contact, liquid droplets produced by one person may be inhaled by another person; droplets larger than 10 μm tend to remain trapped in the nose and throat while smaller droplets will penetrate to the lower respiratory system.

Advanced Computational Fluid Dynamics (CFD) showed that at wind speeds varying from 4 to 15 km/h, respiratory droplets may travel up to 6 meters.

Role in disease transmission

Illustration of a respiratory droplet, showing mucins (green), surfactant proteins and lipids (blue) and a coronavirus particle (pink)

A common form of disease transmission is by way of respiratory droplets, generated by coughing, sneezing, or talking. Respiratory droplet transmission is the usual route for respiratory infections. Transmission can occur when respiratory droplets reach susceptible mucosal surfaces, such as in the eyes, nose or mouth. This can also happen indirectly via contact with contaminated surfaces when hands then touch the face. Respiratory droplets are large and cannot remain suspended in the air for long, and are usually dispersed over short distances.

Viruses spread by droplet transmission include influenza virus, rhinovirus, respiratory syncytial virus, enterovirus, and norovirus; measles morbillivirus; and coronaviruses such as SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 that causes COVID-19. Bacterial and fungal infection agents may also be transmitted by respiratory droplets. By contrast, a limited number of diseases can be spread through airborne transmission after the respiratory droplet dries out. We all continuously breathe out these droplets, but in addition some medical procedures called aerosol-generating medical procedures also generate droplets.

Ambient temperature and humidity affect the survivability of bioaerosols because as the droplet evaporates and becomes smaller, it provides less protection for the infectious agents it may contain. In general, viruses with a lipid envelope are more stable in dry air, while those without an envelope are more stable in moist air. Viruses are also generally more stable at low air temperatures.

Measures taken to reduce transmission

In a healthcare setting, precautions include housing a patient in an individual room, limiting their transport outside the room and using proper personal protective equipment. It has been noted that during the 2002–2004 SARS outbreak, use of surgical masks and N95 respirators tended to decrease infections of healthcare workers. However, surgical masks are much less good at filtering out small droplets/particles than N95 and similar respirators, so the respirators offer greater protection.

Also, higher ventilation rates can be used as a hazard control to dilute and remove respiratory particles. However, if unfiltered or insufficiently filtered air is exhausted to another location, it can lead to spreading of an infection.

History

World-War-II-era UK public-health-education poster.

German bacteriologist Carl Flügge in 1899 was the first to show that microorganisms in droplets expelled from the respiratory tract are a means of disease transmission. In the early 20th century, the term Flügge droplet was sometimes used for particles that are large enough to not completely dry out, roughly those larger than 100 μm.

Flügge's concept of droplets as primary source and vector for respiratory transmission of diseases prevailed into the 1930s until William F. Wells differentiated between large and small droplets. He developed the Wells curve, which describes how the size of respiratory droplets influences their fate and thus their ability to transmit disease.

See also

References

  1. ^ Johnson, G.R.; Morawska, L.; Ristovski, Z.D.; Hargreaves, M.; Mengersen, K.; Chao, C.Y.H.; Wan, M.P.; Li, Y.; Xie, X.; Katoshevski, D.; Corbett, S. (2011-12-01). "Modality of human expired aerosol size distributions". Journal of Aerosol Science. 42 (12): 839–851. Bibcode:2011JAerS..42..839J. doi:10.1016/j.jaerosci.2011.07.009. ISSN 0021-8502.
  2. ^ Gregson, Florence K. A.; Watson, Natalie A.; Orton, Christopher M.; Haddrell, Allen E.; McCarthy, Lauren P.; Finnie, Thomas J. R.; Gent, Nick; Donaldson, Gavin. C.; Shah, Pallav L.; Calder, James D.; Bzdek, Bryan R. (2021-02-26). "Comparing aerosol concentrations and particle size distributions generated by singing, speaking and breathing". Aerosol Science and Technology. 55 (6): 681–691. Bibcode:2021AerST..55..681G. doi:10.1080/02786826.2021.1883544. hdl:10044/1/87506. ISSN 0278-6826. S2CID 233353106.
  3. ^ Bourouiba, Lydia (2021-01-05). "The Fluid Dynamics of Disease Transmission". Annual Review of Fluid Mechanics. 53 (1): 473–508. Bibcode:2021AnRFM..53..473B. doi:10.1146/annurev-fluid-060220-113712. ISSN 0066-4189. S2CID 225114407.
  4. Hunziker, Patrick (2021-10-01). "Minimising exposure to respiratory droplets, 'jet riders' and aerosols in air-conditioned hospital rooms by a 'Shield-and-Sink' strategy". BMJ Open. 11 (10): e047772. doi:10.1136/bmjopen-2020-047772. ISSN 2044-6055. PMC 8520596. PMID 34642190.
  5. Wilson, Nick; Corbett, Stephen; Tovey, Euan (2020). "Airborne transmission of Covid-19". BMJ. 370: m3206. doi:10.1136/bmj.m3206. ISSN 1756-1833. PMID 32819961. S2CID 221178291.
  6. ^ Atkinson, James; Chartier, Yves; Pessoa-Silva, Carmen Lúcia; Jensen, Paul; Li, Yuguo; Seto, Wing-Hong (2009). "Annex C: Respiratory droplets". Natural Ventilation for Infection Control in Health-Care Settings. World Health Organization. ISBN 978-92-4-154785-7.
  7. Environmental Health Matters Initiative; National Academies of Sciences, Engineering, and Medicine (2020-10-22). Shelton-Davenport, Marilee; Pavlin, Julie; Saunders, Jennifer; Staudt, Amanda (eds.). Airborne Transmission of SARS-CoV-2: Proceedings of a Workshopâ€"in Brief. Washington, D.C.: National Academies Press. doi:10.17226/25958. ISBN 978-0-309-68408-8. PMID 33119244. S2CID 236828761.{{cite book}}: CS1 maint: multiple names: authors list (link)
  8. ^ Morawska, L. (2006-10-01). "Droplet fate in indoor environments, or can we prevent the spread of infection?" (PDF). Indoor Air. 16 (5): 335–347. Bibcode:2006InAir..16..335M. doi:10.1111/j.1600-0668.2006.00432.x. ISSN 0905-6947. PMID 16948710. S2CID 36940738.
  9. ^ Gralton, Jan; Tovey, Euan; McLaws, Mary-Louise; Rawlinson, William D. (2011-01-01). "The role of particle size in aerosolised pathogen transmission: A review". Journal of Infection. 62 (1): 1–13. doi:10.1016/j.jinf.2010.11.010. PMC 7112663. PMID 21094184.
  10. ^ Dbouk, Talib; Drikakis, Dimitris (2020). "On coughing and airborne droplet transmission to humans". Physics of Fluids. 32 (5): 053310. Bibcode:2020PhFl...32e3310D. doi:10.1063/5.0011960. PMC 7239332. PMID 32574229.
  11. ^ Wells, W. F. (1934). "On air-borne infection: study II. Droplets and droplet nuclei". American Journal of Epidemiology. 20 (3): 611–618. doi:10.1093/oxfordjournals.aje.a118097.
  12. "Clinical Educators Guide for the prevention and control of infection in healthcare". Australian National Health and Medical Research Council. 2010. p. 3. Archived (PDF) from the original on 2015-04-05. Retrieved 2015-09-12.
  13. ^ La Rosa, Giuseppina; Fratini, Marta; Della Libera, Simonetta; Iaconelli, Marcello; Muscillo, Michele (2013-06-01). "Viral infections acquired indoors through airborne, droplet or contact transmission". Annali dell'Istituto Superiore di Sanità. 49 (2): 124–132. doi:10.4415/ANN_13_02_03. ISSN 0021-2571. PMID 23771256.
  14. ^ "FAQ: Methods of Disease Transmission". Mount Sinai Hospital (Toronto). Retrieved 2020-03-31.
  15. Van Doremalen, Neeltje; Bushmaker, Trenton; Morris, Dylan H.; Holbrook, Myndi G.; Gamble, Amandine; Williamson, Brandi N.; Tamin, Azaibi; Harcourt, Jennifer L.; Thornburg, Natalie J.; Gerber, Susan I.; Lloyd-Smith, James O.; De Wit, Emmie; Munster, Vincent J. (2020). "Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1". New England Journal of Medicine. 382 (16): 1564–1567. doi:10.1056/NEJMc2004973. PMC 7121658. PMID 32182409. S2CID 212752423.
  16. "Pass the message: Five steps to kicking out coronavirus". World Health Organization. 2020-02-23. Retrieved 2020-03-24.
  17. "Transmission-Based Precautions". U.S. Centers for Disease Control and Prevention. 2016-01-07. Retrieved 2020-03-31.
  18. "Prevention of hospital-acquired infections" (PDF). World Health Organization (WHO). p. 45. Archived from the original (PDF) on 26 March 2020.
  19. Gamage, B; Moore, D; Copes, R; Yassi, A; Bryce, E (2005-03-01). "Protecting health care workers from SARS and other respiratory pathogens: A review of the infection control literature". American Journal of Infection Control. 33 (2): 114–121. doi:10.1016/j.ajic.2004.12.002. PMC 7132691. PMID 15761412.
  20. "N95 Respirators and Surgical Masks (Face Masks)". U.S. Food and Drug Administration. 2020-03-11. Retrieved 2020-03-28.
  21. Konda, Abhiteja; Prakash, Abhinav; Moss, Gregory A.; Schmoldt, Michael; Grant, Gregory D.; Guha, Supratik (2020-05-26). "Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks". ACS Nano. 14 (5): 6339–6347. doi:10.1021/acsnano.0c03252. ISSN 1936-0851. PMC 7185834. PMID 32329337.
  22. Hare, R. (1964-03-01). "The transmission of respiratory infections". Proceedings of the Royal Society of Medicine. 57 (3): 221–230. doi:10.1177/003591576405700329. ISSN 0035-9157. PMC 1897886. PMID 14130877.
  23. Bourouiba, Lydia (2020-03-26). "Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19". JAMA. 323 (18): 1837–1838. doi:10.1001/jama.2020.4756. ISSN 0098-7484. PMID 32215590.
  24. World Health Organization; Y. Chartier; C. L Pessoa-Silva (2009). Natural Ventilation for Infection Control in Health-care Settings. World Health Organization. p. 79. ISBN 978-92-4-154785-7.
Categories: