Duduzile is a feminine given name, derived from the Nguni word duduza, meaning "to comfort." Notable people with the name include:
- Duduzile Manana, South African politician
- Duduzile Ngcobo (born 1967), South African actress
- Duduzile Sibiya (born 1957), South African politician
- Duduzile Zuma-Sambudla (born 1982), South African politician
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