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EFCAB6

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Protein-coding gene in the species Homo sapiens
EFCAB6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WLZ, 5D67

Identifiers
AliasesEFCAB6, DJBP, HSCBCIP1, dJ185D5.1, EF-hand calcium binding domain 6
External IDsMGI: 1924877; HomoloGene: 11259; GeneCards: EFCAB6; OMA:EFCAB6 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)
Chromosome 22 (human)Genomic location for EFCAB6Genomic location for EFCAB6
Band22q13.2-q13.31Start43,528,744 bp
End43,812,337 bp
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)
Chromosome 15 (mouse)Genomic location for EFCAB6Genomic location for EFCAB6
Band15|15 E1- E2Start83,750,913 bp
End83,949,580 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • sperm

  • buccal mucosa cell

  • right uterine tube

  • bronchial epithelial cell

  • oocyte

  • testicle

  • olfactory zone of nasal mucosa

  • gonad
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • zygote

  • primary oocyte

  • secondary oocyte

  • muscle of thigh

  • temporal muscle

  • cornea

  • skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64800

77627

Ensembl

ENSG00000186976

ENSMUSG00000022441

UniProt

Q5THR3

Q6P1E8

RefSeq (mRNA)

NM_022785
NM_198856

NM_001161628
NM_001161629
NM_029946

RefSeq (protein)

NP_073622
NP_942153

NP_001155100
NP_001155101
NP_084222

Location (UCSC)Chr 22: 43.53 – 43.81 MbChr 15: 83.75 – 83.95 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

EF-hand calcium-binding domain-containing protein 6 is a protein that in humans is encoded by the EFCAB6 gene.


Interactions

EFCAB6 has been shown to interact with PARK7 and Androgen receptor.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000186976Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022441Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (Mar 2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
  6. ^ Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Mar 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Mol Cancer Res. 1 (4): 247–61. PMID 12612053.
  7. "Entrez Gene: FLJ23588 CAP-binding protein complex interacting protein 1".

Further reading

PDB gallery
  • 1wlz: Crystal structure of DJBP fragment which was obtained by limited proteolysis 1wlz: Crystal structure of DJBP fragment which was obtained by limited proteolysis


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