ELAV-like protein 2 - Misplaced Pages

(Redirected from ELAVL2) Protein-coding gene in the species Homo sapiens

ELAVL2

Identifiers

ELAVL2, HEL-N1, HELN1, HUB, ELAV like neuron-specific RNA binding protein 2, ELAV like RNA binding protein 2

External IDs

OMIM: 601673; MGI: 1100887; HomoloGene: 20930; GeneCards: ELAVL2; OMA:ELAVL2 - orthologs

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4 C5\|4 42.36 cM	Start	91,250,763 bp
Band	4 C5\|4 42.36 cM	End	91,400,785 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

n/a

Top expressed in

superior cervical ganglion

facial motor nucleus

Rostral migratory stream

mammillary body

medial ganglionic eminence

medial dorsal nucleus

medial vestibular nucleus

lateral hypothalamus

pontine nuclei

dorsomedial hypothalamic nucleus

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding mRNA 3'-UTR binding nucleic acid binding RNA binding
Cellular component	nucleoplasm
Biological process	regulation of transcription, DNA-templated mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1993


15569

Ensembl


ENSG00000107105


ENSMUSG00000008489

UniProt


Q12926


Q60899

RefSeq (mRNA)


NM_001171195 NM_001171197 NM_004432

NM_001177883 NM_010486 NM_207685 NM_207686 NM_001347149
NM_001357188 NM_001357189

RefSeq (protein)

NP_001164666 NP_001164668 NP_004423 NP_001338384 NP_001338385
NP_001338386 NP_001338387 NP_001338388 NP_001338389 NP_001338390 NP_001338391 NP_001338392 NP_001338393 NP_001338394 NP_001338395 NP_001338396 NP_001338397 NP_001338398 NP_001338399 NP_001338400 NP_001338401 NP_001338402 NP_001338403 NP_001338404 NP_001338405 NP_001338406 NP_001338407

NP_001171354 NP_001334078 NP_034616 NP_997568 NP_997569
NP_001344117 NP_001344118 NP_001361165 NP_001361166 NP_001361167 NP_001361625

Location (UCSC)

n/a

Chr 4: 91.25 – 91.4 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.

References

^ GRCm38: Ensembl release 89: ENSMUSG00000008489 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics. 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID 8812435.
"Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. Bibcode:1994PNAS...9111207G. doi:10.1073/pnas.91.23.11207. PMC 45196. PMID 7972035.
King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor". J. Neurosci. 14 (4): 1943–52. doi:10.1523/JNEUROSCI.14-04-01943.1994. PMC 6577146. PMID 8158249.
Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation". J. Cell Sci. 109 (3): 579–89. doi:10.1242/jcs.109.3.579. PMID 8907704.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation". J. Biol. Chem. 280 (13): 12690–9. doi:10.1074/jbc.M411119200. PMID 15671036.

v t e PDB gallery
1d8z: SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC) 1d9a: SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC) 1fnx: SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT 1fxl: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA 1g2e: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA

PDB gallery

1d8z: SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC)
1d9a: SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC)
1fnx: SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT
1fxl: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE C-FOS RNA
1g2e: CRYSTAL STRUCTURE OF HUD AND AU-RICH ELEMENT OF THE TUMOR NECROSIS FACTOR ALPHA RNA

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