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EPGN
Identifiers
Aliases	EPGN, ALGV3072, EPG, PRO9904, epithelial mitogen
External IDs	MGI: 1919170; HomoloGene: 19527; GeneCards: EPGN; OMA:EPGN - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.3 Start 74,308,470 bp End 74,316,789 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E1 Start 91,175,323 bp End 91,183,074 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of esophagus vagina skin of leg appendix skin of abdomen right lung tonsil bone marrow cells ectocervix mucosa of transverse colon Top expressed in embryo cornea embryo hair follicle spermatid lip skin of abdomen conjunctival fornix skin of back muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function epidermal growth factor receptor binding growth factor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane intracellular anatomical structure membrane extracellular space clathrin-coated vesicle membrane Biological process positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of MAP kinase activity angiogenesis positive regulation of cell population proliferation MAPK cascade positive regulation of epithelial cell proliferation epidermal growth factor receptor signaling pathway signal transduction negative regulation of epidermal growth factor receptor signaling pathway positive regulation of protein kinase B signaling membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255324 71920 Ensembl ENSG00000182585 ENSMUSG00000035020 UniProt Q6UW88 Q924X1 RefSeq (mRNA) NM_001013442 NM_001270989 NM_001270990 NM_001270991 NM_001270992 NM_001270993 NM_053087 RefSeq (protein) NP_001257918 NP_001257919 NP_001257920 NP_001257921 NP_001257922 NP_444317 Location (UCSC) Chr 4: 74.31 – 74.32 Mb Chr 5: 91.18 – 91.18 Mb PubMed search
Wikidata
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Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.

Function

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000182585 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035020 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: Epithelial mitogen".
6. Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

External links

• epigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

• Genes on human chromosome 4