EPHA10 - Misplaced Pages

Protein-coding gene in the species Homo sapiens

EPHA10

Identifiers

EPHA10, EPH receptor A10

External IDs

OMIM: 611123; MGI: 3586824; HomoloGene: 67804; GeneCards: EPHA10; OMA:EPHA10 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p34.3	Start	37,713,880 bp
Band	1p34.3	End	37,765,133 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4\|4 D2.2	Start	124,880,899 bp
Band	4\|4 D2.2	End	124,917,800 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

mucosa of transverse colon

left testis

right testis

rectum

mucosa of ileum

right frontal lobe

Brodmann area 9

nucleus accumbens

epithelium of colon

Top expressed in

piriform cortex

primary visual cortex

superior colliculus

ventral tegmental area

superior frontal gyrus

pontine nuclei

medial vestibular nucleus

medial dorsal nucleus

dorsal tegmental nucleus

inferior colliculi

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity transmembrane-ephrin receptor activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity receptor tyrosine kinase transmembrane signaling receptor activity
Cellular component	integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region cytoplasm neuron projection receptor complex
Biological process	phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway biological process negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


284656


230735

Ensembl


ENSG00000183317


ENSMUSG00000028876

UniProt


Q5JZY3


Q8BYG9

RefSeq (mRNA)


NM_001004338 NM_001099439 NM_173641


NM_001256432 NM_177671

RefSeq (protein)


NP_001092909 NP_775912


NP_001243361 NP_808339

Location (UCSC)

Chr 1: 37.71 – 37.77 Mb

Chr 4: 124.88 – 124.92 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

EPH receptor A10 is a protein in humans that is encoded by the EPHA10 gene.

Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells.

References

^ GRCh38: Ensembl release 89: ENSG00000183317 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000028876 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aasheim HC, Patzke S, Hjorthaug HS, Finne EF (May 2005). "Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis". Biochimica et Biophysica Acta (BBA) - General Subjects. 1723 (1–3): 1–7. doi:10.1016/j.bbagen.2005.01.011. PMID 15777695.

Growth factor receptor modulators

Angiopoietin

Agonists: Angiopoietin 1
Angiopoietin 4

Antagonists: Angiopoietin 2
Angiopoietin 3

Kinase inhibitors: Altiratinib
CE-245677
Rebastinib

Antibodies: Evinacumab (against angiopoietin 3)
Nesvacumab (against angiopoietin 2)

CNTF

Agonists: Axokine
CNTF
Dapiclermin

EGF (ErbB)

EGF (ErbB1/HER1)	Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen Epiregulin Heparin-binding EGF-like growth factor (HB-EGF) Murodermin Nepidermin Transforming growth factor alpha (TGFα) Kinase inhibitors: Afatinib Agerafenib Brigatinib Canertinib Dacomitinib Erlotinib Gefitinib Grandinin Icotinib Lapatinib Neratinib Osimertinib Vandetanib WHI-P 154 Antibodies: Cetuximab Depatuxizumab Depatuxizumab mafodotin Futuximab Imgatuzumab Matuzumab Necitumumab Nimotuzumab Panitumumab Zalutumumab
ErbB2/HER2	Agonists: Unknown/none Antibodies: Ertumaxomab Pertuzumab Trastuzumab Trastuzumab deruxtecan Trastuzumab duocarmazine Trastuzumab emtansine Kinase inhibitors: Afatinib Lapatinib Mubritinib Neratinib Tucatinib
ErbB3/HER3	Agonists: Neuregulins (heregulins) (1, 2, 6 (neuroglycan C)) Antibodies: Duligotumab Patritumab Seribantumab
ErbB4/HER4	Agonists: Betacellulin Epigen Heparin-binding EGF-like growth factor (HB-EGF) Neuregulins (heregulins) (1, 2, 3, 4, 5 (tomoregulin, TMEFF))

FGF

FGFR1	Agonists: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 8, 10 (KGF2), 20) Repifermin Selpercatinib Trafermin Velafermin
FGFR2	Agonists: Ersofermin FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22) Palifermin Repifermin Selpercatinib Sprifermin Trafermin Antibodies: Aprutumab Aprutumab ixadotin Kinase inhibitors: Infigratinib
FGFR3	Agonists: Ersofermin FGF (1, 2 (bFGF), 4, 8, 9, 18, 23) Selpercatinib Sprifermin Trafermin Antibodies: Burosumab (against FGF23)
FGFR4	Agonists: Ersofermin FGF (1, 2 (bFGF), 4, 6, 8, 9, 19) Trafermin
Unsorted	Agonists: FGF15/19

HGF (c-Met)

Agonists: Fosgonimeton
Hepatocyte growth factor

Potentiators: Dihexa (PNB-0408)

IGF

IGF-1

IGF-2

Agonists: Insulin-like growth factor-2 (somatomedin A)

Antibodies: Dusigitumab
Xentuzumab (against IGF-1 and IGF-2)

Others

Binding proteins: IGFBP (1, 2, 3, 4, 5, 6, 7)

Cleavage products/derivatives with unknown target: Glypromate (GPE, (1-3)IGF-1)
Trofinetide

LNGF (p75)

Antibodies: Against NGF: ABT-110 (PG110)
ASP-6294
Fasinumab
Frunevetmab
Fulranumab
MEDI-578
Ranevetmab
Tanezumab

Aptamers: Against NGF: RBM-004

Decoy receptors: LEVI-04 (p75-Fc)

PDGF

Agonists: Becaplermin
Platelet-derived growth factor (A, B, C, D)

RET (GFL)

GFRα1	Agonists: Glial cell line-derived neurotrophic factor (GDNF) Liatermin Kinase inhibitors: Vandetanib
GFRα2	Agonists: Neurturin (NRTN) Kinase inhibitors: Vandetanib
GFRα3	Agonists: Artemin (ARTN) Kinase inhibitors: Vandetanib
GFRα4	Agonists: Persephin (PSPN) Kinase inhibitors: Vandetanib
Unsorted	Kinase inhibitors: Agerafenib