Efe or EFE may refer to:
People
- Efé people, an ethnic group in the Democratic Republic of the Congo
- Efe (zeybek), leaders of Turkish outlaws and soldiers
- Efe (musician) (born 1993), Nigerian musician and media personality
Given name
- Ali Efe Yeğin (born 1993), Turkish professional motorcycle racer
- Efe Abogidi (born 2001), Nigerian basketball player
- Efe Aydan (born 1955), Turkish former professional basketball player
- Efe Cakarel, Turkish entrepreneur
- Efe Ambrose (born 1988), Nigerian footballer
- Efe İnanç (born 1980), Turkish footballer
- Efe Obada (born 1992), Nigerian-American football player
- Efe Özarslan (born 1990), Turkish footballer
- Efe Paul Azino (born 1979), Nigerian writer
Surname
- Gökçen Efe (1881–1919), Turkish folk hero
- Sam Loco Efe (1945–2011), Nigerian actor and director
Science and engineering
- 2-oxoglutarate dioxygenase (ethylene-forming)
- 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
- Early fuel evaporator
- Einstein field equations
- Endocardial fibroelastosis, a heart condition in young children
- External field effect in Modified Newtonian dynamics
Other uses
- Efe, one of the nine default skins in the game Minecraft.
- EFE, a Spanish news agency
- Efe language
- Empresa de Ferrocarriles Ecuatorianos, the national railway of Ecuador
- Empresa de los Ferrocarriles del Estado, the national railway of Chile
- Exclusive First Editions, a British die-cast bus model manufacturer
- Trofeo EFE, a Spanish football award
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