| Enterovirus cis-acting replication element | |
|---|---|
 Predicted secondary structure and sequence conservation of Entero_CRE | |
| Identifiers | |
| Symbol | Entero_CRE |
| Alt. Symbols | CRE |
| Rfam | RF00048 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation. The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.
See also
References
- Paul AV, Rieder E, Kim DW, van Boom JH, Wimmer E (November 2000). "Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg". Journal of Virology. 74 (22): 10359–10370. doi:10.1128/JVI.74.22.10359-10370.2000. PMC 110910. PMID 11044080.
- Goodfellow I, Chaudhry Y, Richardson A, Meredith J, Almond JW, Barclay W, Evans DJ (May 2000). "Identification of a cis-acting replication element within the poliovirus coding region". Journal of Virology. 74 (10): 4590–4600. doi:10.1128/JVI.74.10.4590-4600.2000. PMC 111979. PMID 10775595.
External links
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