Escom or ESCOM may refer to:
- Escom AG, a defunct German computer corporation
- Escom LLC, Internet corporation best known as the former owner of the "sex.com" web domain
- ESCOM IPN, the Superior School of Computer Sciences of the National Polytechnic Institute of Mexico
- École supérieure de chimie organique et minérale, a French grande école for chemical engineering
- Eskom, South African electricity public utility, known as ESCOM until 1986
- Electricity Supply Commission of Malawi (ESCOM), Ltd, state-owned power producing company in Malawi
- European Society for the Cognitive Sciences of Music, non-profit learned society supporting research in the cognitive sciences of music
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