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In enzymology, an estradiol 6beta-monooxygenase (EC 1.14.99.11) is an enzyme that catalyzes the chemical reaction

estradiol-17beta + AH₂ + O₂ ${\displaystyle \rightleftharpoons }$ 6beta-hydroxyestradiol-17beta + A + H₂O

The 3 substrates of this enzyme are estradiol-17beta, an electron acceptor AH₂, and O₂, whereas its 3 products are 6beta-hydroxyestradiol-17beta, the reduction product A, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating). This enzyme is also called estradiol 6beta-hydroxylase. This enzyme participates in androgen and estrogen metabolism.

References

• Haines WJ (1952). "The biosynthesis of adrenal cortex hormones". Recent Progr. Hormone Res. 7: 255–305.
• Mueller GC, Rumney G (1957). "Formation of 6beta-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes". J. Am. Chem. Soc. 79 (4): 1004–1005. doi:10.1021/ja01561a068.

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