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FBXW8

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Protein-coding gene in humans

FBXW8
Identifiers
AliasesFBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDsOMIM: 609073; MGI: 1923041; HomoloGene: 17731; GeneCards: FBXW8; OMA:FBXW8 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)
Chromosome 12 (human)Genomic location for FBXW8Genomic location for FBXW8
Band12q24.22Start116,910,950 bp
End117,031,148 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for FBXW8Genomic location for FBXW8
Band5|5 FStart118,203,030 bp
End118,293,529 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • gonad

  • ventricular zone

  • bone marrow cells

  • islet of Langerhans

  • ganglionic eminence

  • epithelium of colon

  • testicle

  • popliteal artery

  • tibial arteries
Top expressed in
  • otic vesicle

  • otic placode

  • saccule

  • interventricular septum

  • internal carotid artery

  • external carotid artery

  • somite

  • calvaria

  • yolk sac

  • lumbar spinal ganglion
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26259

231672

Ensembl

ENSG00000174989

ENSMUSG00000032867

UniProt

Q8N3Y1

Q8BIA4

RefSeq (mRNA)

NM_012174
NM_153348

NM_172721

RefSeq (protein)

NP_036306
NP_699179

NP_766309

Location (UCSC)Chr 12: 116.91 – 117.03 MbChr 5: 118.2 – 118.29 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000174989Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000032867Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. ^ "Entrez Gene: FBXW8 F-box and WD repeat domain containing 8".

Further reading


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