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FCE 28260

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(Redirected from FCE 28,260) Chemical compound Pharmaceutical compound
FCE 28260
Clinical data
Other namesPNU 156765
Routes of
administration		Oral
ATC code
  • none
Identifiers
IUPAC name
  • (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-N-((2RS)-1,1,1-trifluoro-2-phenyl-2-propanyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indenoquinoline-7-carboxamide
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC28H35F3N2O2
Molar mass488.595 g·mol
3D model (JSmol)
SMILES
  • FC(F)(F)C(c1ccccc1)(NC(=O)32(CC4(2CC3)CC5NC(=O)\C=C/45C)C)C
InChI
  • InChI=1S/C28H35F3N2O2/c1-25-15-13-20-18(9-12-22-26(20,2)16-14-23(34)32-22)19(25)10-11-21(25)24(35)33-27(3,28(29,30)31)17-7-5-4-6-8-17/h4-8,14,16,18-22H,9-13,15H2,1-3H3,(H,32,34)(H,33,35)/t18-,19-,20-,21+,22+,25-,26+,27?/m0/s1
  • Key:FAIZUAWLKOHMOP-ZOIXLQFFSA-N

FCE 28260 is an azasteroidal 5α-reductase inhibitor which was developed for the treatment of benign prostatic hyperplasia and androgenic alopecia (pattern hair loss) in the 1990s but was never marketed. FCE 28260 has been found to inhibit rat and human 5α-reductase with half-maximal inhibitory concentrations (IC50) of 15 and 16 nM, respectively, while finasteride had values of 30 and 52 nM.

References

  1. ^ Giudici D, Briatico G, Cominato C, Zaccheo T, Iehlè C, Nesi M, et al. (June 1996). "FCE 28260, a new 5 alpha-reductase inhibitor: in vitro and in vivo effects". The Journal of Steroid Biochemistry and Molecular Biology. 58 (3): 299–305. doi:10.1016/0960-0760(96)00040-4. PMID 8836165. S2CID 140209512.
  2. EP 0782582, di Salle E, Nesi M, Panzeri A, "Epimers of (22RS)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide", published 1997-07-09 
  3. "FCE 28260". AdisInsight. Springer Nature Switzerland AG.
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