FDE may refer to:
- Flower Delivery Express, an American floral and gifts retailer
- Fault detection and exclusion, a technique used in global positioning systems
- Federal Directorate of Education, an agency of the Pakistani government
- Fetch-decode-execute cycle, in computer science
- First-degree entailment, a weakening of the Logic of Paradox lacking truths
- Førde Airport, Bringeland, in Norway
- Førde Airport, Øyrane, in Norway, closed in 1986
- Forensic document examination, a synonym of "questioned document examination"
- FrameMaker Development Environment, part of Adobe FrameMaker
- Full disk encryption
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