FGI-104 - Misplaced Pages

Chemical compound Pharmaceutical compound

FGI-104
Legal status

Legal status	US: Investigational New Drug
Identifiers
IUPAC name 4--2-(diethylaminomethyl)-6-phenol
PubChem CID	44158960
ChemSpider	65322076
CompTox Dashboard (EPA)	DTXSID201028023
Chemical and physical data
Formula	C₂₈H₃₀ClN₃O₃
Molar mass	492.02 g·mol
3D model (JSmol)	Interactive image
SMILES c4cnc1cc(Cl)ccc1c4Nc(cc2CN(CC)CC)cc(c2O)-c(cc3OC)ccc3CO
InChI InChI=1S/C28H30ClN3O3/c1-4-32(5-2)16-20-12-22(31-25-10-11-30-26-14-21(29)8-9-23(25)26)15-24(28(20)34)18-6-7-19(17-33)27(13-18)35-3/h6-15,33-34H,4-5,16-17H2,1-3H3,(H,30,31) Key:OFXBJOIYAJBMNY-UHFFFAOYSA-N

FGI-104 is the name of an experimental broad-spectrum antiviral drug, with activity against a range of viruses including hepatitis B, hepatitis C, HIV, Ebola virus, and Venezuelan equine encephalitis virus.

Mechanism

The drug acts by inhibiting the protein TSG101, which transports newly manufactured virions to the exterior of an infected cell, thus breaking the replication cycle of the virus. In pre-clinical studies, FGI-104 has been shown to protect mice from Ebola virus disease.

References

Kinch MS, Yunus AS, Lear C, Mao H, Chen H, Fesseha Z, et al. (January 2009). "FGI-104: a broad-spectrum small molecule inhibitor of viral infection". American Journal of Translational Research. 1 (1): 87–98. doi:10.1016/j.antiviral.2009.02.082. PMC 2776286. PMID 19966942.
Janeba Z (November 2015). "Development of Small-Molecule Antivirals for Ebola". Medicinal Research Reviews. 35 (6): 1175–94. doi:10.1002/med.21355. PMC 7168439. PMID 26172225.
Saxena A, Ferri M (2015). "Clinical Management of Ebola Virus Disease: Current and Future Approaches". In Saxena A (ed.). Communicable Diseases of the Developing World. Topics in Medicinal Chemistry. Vol. 29. Cham: Springer. pp. 1–36. doi:10.1007/7355_2015_5003. ISBN 978-3-319-78252-2.

Filoviridae

Ebolavirus

Outbreaks	1976 Sudan outbreak 1976 Zaire outbreak 2013−2016 West African Ebola virus epidemic Timeline Reported cases and deaths Responses United Nations Ebola Response Fund Operation United Assistance in Guinea in Liberia in Mali in Nigeria in Sierra Leone in Spain in the US in the UK Ouse to Ouse Tock Womey massacre Recent DR Congo outbreaks and epidemics 2014 2017 2018 Équateur Kivu epidemic 2020 Équateur 2021 North Kivu
Species	Bundibugyo ebolavirus BDBV Reston ebolavirus RESTV Sudan ebolavirus SUDV Taï Forest ebolavirus TAFV Zaire ebolavirus EBOV
Drug candidates	BCX4430 Brincidofovir DZNep Favipiravir FGI-103 FGI-104 FGI-106 JK-05 Lamivudine mAb114 TKM-Ebola (failed) Triazavirin ZMapp Vaccines cAd3-ZEBOV
Drugs	Vaccines rVSV-ZEBOV
Notable people	Ebola researchers William Close Jean-Jacques Muyembe-Tamfum Peter Piot Ebola patients Ameyo Adadevoh Kent Brantly Pauline Cafferkey Thomas Eric Duncan Salome Karwah Sheik Umar Khan Matthew Lukwiya Mayinga N'Seka Patrick Sawyer
Popular culture	The Hot Zone (1995 book by Richard Preston) Outbreak (1995 film) Ebola Syndrome (1996 film) Executive Orders (1996 novel) Ebola-chan (2014 meme) 93 Days (2016 film) The Hot Zone (2019 miniseries based on Preston book)
Miscellaneous	Ebola virus disease Ebola virus disease treatment research Ebola River

Marburgvirus

Outbreaks	1967 Marburg virus outbreak in West Germany 2017 Uganda Marburg virus outbreak 2021 Marburg virus disease outbreak in Guinea 2022 Marburg virus disease outbreak in Ghana 2023 Marburg virus disease outbreak in Equatorial Guinea 2023 Marburg virus disease outbreak in Tanzania 2024 Marburg virus disease outbreak in Rwanda
Species	Marburg marburgvirus MARV RAVV
Drug candidates	BCX4430 FGI-103 FGI-106
Popular culture	The Hot Zone (1995 book)
Miscellaneous	Marburg virus disease Marburg

Cuevavirus

Species	Lloviu cuevavirus (LLOV)

Dianlovirus

Species	Mengla virus (MLAV)

Striavirus

Species	Xilang striavirus

Thamnovirus

Species	Huangjiao thamnovirus

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Categories:

Mechanism

See also

References