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TAFA4
Identifiers
Aliases	TAFA4, TAFA-4, family with sequence similarity 19 (chemokine (C-C motif)-like), member A4, family with sequence similarity 19 member A4, C-C motif chemokine like, TAFA chemokine like family member 4, FAM19A4
External IDs	OMIM: 617498; MGI: 2444563; HomoloGene: 18561; GeneCards: TAFA4; OMA:TAFA4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p14.1 Start 68,731,766 bp End 68,953,297 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D3 Start 96,808,164 bp End 97,037,374 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle oocyte secondary oocyte lateral nuclear group of thalamus right adrenal cortex decidua C1 segment left adrenal gland left adrenal cortex prefrontal cortex Top expressed in lumbar spinal ganglion cumulus cell primary oocyte embryo secondary oocyte embryo zygote morula epithelium of lens spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding receptor ligand activity Cellular component extracellular region extracellular space Biological process regulation of membrane potential regulation of sensory perception of pain phagocytosis regulation of signaling receptor activity superoxide anion generation macrophage chemotaxis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151647 320701 Ensembl ENSG00000163377 ENSMUSG00000046500 UniProt Q96LR4 Q7TPG5 RefSeq (mRNA) NM_001005527 NM_182522 NM_177233 RefSeq (protein) NP_001005527 NP_872328 NP_001005527.1 NP_872328.1 NP_796207 Location (UCSC) Chr 3: 68.73 – 68.95 Mb Chr 6: 96.81 – 97.04 Mb PubMed search
Wikidata
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Family with sequence similarity 19 member A4, C-C motif chemokine like is a protein that in humans is encoded by the FAM19A4 gene.

Function

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000163377 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000046500 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Family with sequence similarity 19 member A4, C-C motif chemokine like". Retrieved 2017-12-09.

Further reading

• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W (2015). "FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages". Cell. Mol. Immunol. 12 (5): 615–24. doi:10.1038/cmi.2014.61. PMC 4579646. PMID 25109685.
• De Strooper LM, Meijer CJ, Berkhof J, Hesselink AT, Snijders PJ, Steenbergen RD, Heideman DA (2014). "Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions". Cancer Prev Res (Phila). 7 (12): 1251–7. doi:10.1158/1940-6207.CAPR-14-0237. PMID 25281488.
• Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, Steenbergen RD, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, Van Baal WM, Graziosi PG, Quint WG, Heideman DA, Meijer CJ (2016). "Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)". Int. J. Cancer. 138 (4): 992–1002. doi:10.1002/ijc.29824. PMID 26317579.
• De Strooper LM, Verhoef VM, Berkhof J, Hesselink AT, de Bruin HM, van Kemenade FJ, Bosgraaf RP, Bekkers RL, Massuger LF, Melchers WJ, Steenbergen RD, Snijders PJ, Meijer CJ, Heideman DA (2016). "Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women". Gynecol. Oncol. 141 (2): 341–347. doi:10.1016/j.ygyno.2016.02.012. PMC 4851217. PMID 26921784.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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