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The first total synthesis of fascaplysin was performed in seven steps from indole in 1990. Fascaplysin and its derivatives can be synthesized from tryptamine, beta-carboline, indoleketones, and indigo.
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Dubovitskii, Sergey (1996). "Method for synthesis of 12H-pyridodiindoles. Total synthesis of homofascaplysin C". Tetrahedron Letters. 37 (29): 5207–5208. doi:10.1016/0040-4039(96)01052-0.
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Zhidkov, M. (2018). "Syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin and their derivatives". Tetrahedron Letters. 59 (8): 708–711. doi:10.1016/j.tetlet.2018.01.023.