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Fidgetin-like 2 (FL2) is a human enzyme that slows the rate at which skin cells migrate to wounds to heal them. If this enzyme is suppressed/absent, skin cells move faster, speeding the healing process.
Delivery
Molecules of silencing RNA (siRNA) that bind to a gene's messenger RNA (mRNA) can inhibit the production of FL2, but siRNAs require protection from degradation in order to reach a wound site.
In 2015, researchers disclosed the successful use of nanoparticles to ferry siRNA molecules to their intended targets, reducing healing times in mice with skin excisions or burns. The result was normal, well-orchestrated tissue, including hair follicles and supportive collagen network.
References
- ^ Charafeddine, Rabab A.; Makdisi, J; Schairer, D; O'Rourke, BP; Diaz-Valencia, JD; Chouake, J; Kutner, A; Krausz, A; Adler, B; Nacharaju, P; Liang, H; Mukherjee, S; Friedman, JM; Friedman, A; Nosanchuk, JD; Sharp, DJ (10 March 2015). "Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing". The Journal of Investigative Dermatology. 135 (9): 2309–18. doi:10.1038/jid.2015.94. PMC 4537388. PMID 25756798.
- ^ Moss, Richard (March 30, 2015). "Nanoparticles help wounds to heal 50 percent faster". Gizmag. Retrieved 3 April 2015.