Fiery serpent may refer to:
- Boi-tatΓ‘, a Brazilian will-o'-the-wisp or legendary creature
- Dracunculus medinensis, or Guinea worm, a nematode causing dracunculiasis
- Fiery flying serpent, a creature mentioned in the Bible
- Fiery serpents, evil entities common to Slavic mythology
- Xiuhcoatl, an Aztec mythological serpent
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