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Animal testing
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Animal testing Alternatives to animal testing Animal testing regulations History of animal testing History of model organisms IACUC Laboratory animal sources Pain and suffering in laboratory animals Testing cosmetics on animals Toxicology testing Vivisection
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Tipu Aziz Michael Balls Neal D. Barnard Colin Blakemore Simon Festing Gill Langley Ingrid Newkirk Bernard Rollin Jerry Vlasak Syed Ziaur Rahman
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A filtered air positive pressure environment in laboratory animal science is a space that is under positive pressure with respect to the outside world. In this way, no germs that could affect the lab animals or that are a threat to the SPF status can enter the facility. To bring in new air, high efficiency particulate air filters (HEPA) are used.

In some facilities, the opposite is done: negative pressure inside prevents escape of germs to the outside world. This is done when the facility does research on dangerous germs like anthrax.

Next to these obvious things, these facilities can have other special hygiene control elements:

• air locks for personnel, feed, bedding, cages and materials (e.g. autoclave with two doors, one to the inside, one to the outside)
• showers for personnel
• emergency power generator or uninterruptible power supplies

References

1. Anderson, D. P.; King, D. D.; Eidson, C. S.; Kleven, S. H. (1972). "Filtered-Air Positive-Pressure (FAPP) Brooding of Broiler Chickens". Avian Diseases. 16 (1): 20–26. doi:10.2307/1588895. JSTOR 1588895.
2. Grunder, A. A.; Gavora, J. S.; Spencer, J. L.; Turnbull, J. E. (1975). "Prevention of Marek's Disease Using a Filtered Air Positive Pressure House". Poultry Science. 54 (4): 1189–1192. doi:10.3382/ps.0541189.

• Pressure
• Animal testing