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Fipravirimat

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HIV/AIDS treatment experimental drug Pharmaceutical compound
Fipravirimat
Clinical data
Other namesGSK3640254
Legal status
Legal status
  • Investigational
Identifiers
IUPAC name
  • (1R)-4--5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopentachrysen-9-yl]-1-(fluoromethyl)cyclohex-3-ene-1-carboxylic acid
CAS Number
PubChem CID
UNII
KEGG
Chemical and physical data
FormulaC43H67FN2O4S
Molar mass727.08 g·mol
3D model (JSmol)
SMILES
  • CC(=C)1CC2(13CC4(3(CC2)C)(CC54(CC=C(C5(C)C)C6=CC(CC6)(CF)C(=O)O)C)C)NCCN7CCS(=O)(=O)CC7
InChI
  • InChI=1S/C43H67FN2O4S/c1-29(2)31-12-19-43(45-22-23-46-24-26-51(49,50)27-25-46)21-20-40(6)33(36(31)43)8-9-35-39(5)15-13-32(38(3,4)34(39)14-16-41(35,40)7)30-10-17-42(28-44,18-11-30)37(47)48/h10,13,31,33-36,45H,1,8-9,11-12,14-28H2,2-7H3,(H,47,48)/t31-,33+,34-,35+,36+,39-,40+,41+,42+,43-/m0/s1
  • Key:YFSNREBZTKMFEB-DHGHKPCRSA-N

Fipravirimat is an experimental drug for the treatment of HIV/AIDS. It belongs to a class of drugs known as maturation inhibitors.

Fipravirimat was being developed by ViiV Healthcare, but development was stopped in 2023.

See also

References

  1. "Fipravirimat". PubChem. U.S. National Library of Medicine.
  2. Dicker I, Jeffrey JL, Protack T, Lin Z, Cockett M, Chen Y, et al. (January 2022). "GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile". Antimicrobial Agents and Chemotherapy. 66 (1): e0187621. doi:10.1128/AAC.01876-21. PMC 8765437. PMID 34780263.
  3. Waldron, James (2023-04-26). "GSK drops one of 2 maturation inhibitors in HIV pipeline". Retrieved 2023-09-18.
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