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Folate-binding protein

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Class of proteins

Folate-binding protein (FBP) are proteins that bind folate, typically the folate receptors and reduced folate carrier.

FBP can be a marker for ovarian cancer.

FBP can be measured to help in tumour classification to aid treatment, as it is over-expressed (20-80 fold) in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.

Alternative usage

FBP can refer to protein(s) (e.g. extracted from cow's milk) used to do folic acid assays.

References

  1. Kelemen, L. E. (2006). "The role of folate receptor a in cancer development, progression and treatment: Cause, consequence or innocent bystander?". Int. J. Cancer. 119 (2): 243–50. doi:10.1002/ijc.21712. PMID 16453285.
  2. Trowsdale, John; Foulkes, William D.; Jones, Tania A.; Campbell, Ian G. (1991). "Folate-binding Protein Is a Marker for Ovarian Cancer". Cancer Research. 51 (19): 5329–5338. PMID 1717147.
  3. http://www.marketwatch.com/story/galena-biopharma-to-present-at-the-10th-annual-biotechnology-investor-forum-2011-10-21
  4. Sobczyńska-Malefora A, Harrington DJ (November 2018). "Laboratory assessment of folate (vitamin B9) status". Journal of Clinical Pathology. 71 (11): 949–956. doi:10.1136/jclinpath-2018-205048. PMID 30228213. S2CID 52297720.


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