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Fractional synthetic rate

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A fractional synthetic rate (FSR) is the rate at which a precursor compound is incorporated into a product per unit of product mass. The metric has been used to estimate the rate at which proteins, lipids, and lipoproteins are synthesized within humans and other animals. The formula used to calculate the FSR from a stable isotope tracer experiment is:

F S R = initial rate of change in product enrichment initial precursor enrichment {\displaystyle FSR={\frac {\color {Blue}{\text{initial rate of change in product enrichment}}}{\color {Green}{\text{initial precursor enrichment}}}}}

References

  1. ^ Foster DM, Barrett PH, Toffolo G, Beltz WF, Cobelli C (1993). "Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data" (PDF). J. Lipid Res. 34 (12): 2193–2205. doi:10.1016/S0022-2275(20)35360-8. PMID 8301238.
  2. Wilkinson DJ, Hossain T, Hill DS, Phillips BE, Crossland H, Williams J, Loughna P, Churchward-Venne TA, Breen L, Phillips SM, Etheridge T, Rathmacher JA, Smith K, Szewczyk NJ, Atherton PJ (June 2013). "Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism" (PDF). J. Physiol. 591 (11): 2911–2923. doi:10.1113/jphysiol.2013.253203. PMC 3690694. PMID 23551944.


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