Francisco Reyes may refer to:
- Francisco Reyes (equestrian), Argentine equestrian
- Francisco Reyes Morandé, Chilean actor
- Francisco Reyes (colonial-era Filipino banker)
- Francisco Reyes (illustrator), Filipino illustrator
- Francisco Reyes (footballer, born 1990), Honduran football goalkeeper
- Francisco Reyes (footballer, born 1941) (1941-76), Paraguayan football midfielder
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