Frandsen is a surname of Danish origin. It may refer to:
- Aage Frandsen (1890–1968) – Danish gymnast
- Anders Frandsen – Danish actor and musician
- Mikkel Frandsen (1892–1981) – American physical chemist
- John Frandsen (composer) – Danish composer and organist
- Jørgen Frandsen – Danish handball player
- Kevin Frandsen – American baseball player
- Per Frandsen – Danish soccer player
- Rasmus Frandsen (1886–1974) – Danish rower
- Scott Frandsen – Canadian rower
- Thomas Frandsen – Danish soccer player
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