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Frataxin-like domain
mature human frataxin
Identifiers
Symbol	Frataxin_Cyay
Pfam	PF01491
InterPro	IPR002908
SCOP2	1dlx / SCOPe / SUPFAM
TCDB	9.B.21
CDD	cd00503
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, the frataxin-like domain is a protein domain found in proteins including eukaryotic frataxin and bacterial CyaY.

The bacterial CyaY proteins are iron-sulphur cluster (FeS) metabolism proteins which are homologous to eukaryotic frataxin. Partial phylogenetic profiling suggests that CyaY most likely functions as part of the ISC system for FeS cluster biosynthesis, and is supported by experimental data in some species.

References

1. Haft DH, Paulsen IT, Ward N, Selengut JD (2006). "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic". BMC Biol. 4: 29. doi:10.1186/1741-7007-4-29. PMC 1569441. PMID 16930487.
2. Layer G, Ollagnier-de Choudens S, Sanakis Y, Fontecave M (June 2006). "Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU". J. Biol. Chem. 281 (24): 16256–63. doi:10.1074/jbc.M513569200. PMID 16603772.
3. Vivas E, Skovran E, Downs DM (February 2006). "Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo". J. Bacteriol. 188 (3): 1175–9. doi:10.1128/JB.188.3.1175-1179.2006. PMC 1347345. PMID 16428423.

• Protein domains