Frederick Bruce may refer to:
- F. F. Bruce (Frederick Fyvie Bruce, 1910–1990), Scottish Biblical scholar
- Frederick Bruce (diplomat) (1814–1867), British diplomat
- Frederick Malloch Bruce (1912–1997), Scottish electrical engineer and educationalist
See also
- Frederick Nanka-Bruce (1878–1953), physician, journalist and politician in the Gold Coast
- Frederick Bruce-Lyle (1953–2016), Ghanaian-born judge who served in the Caribbean
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